Rho GTPase Activating Protein 23 (ARHGAP23)

The RHO family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP.

The deduced protein shares significant similarity with a C. elegans GTPase-activating protein. RT-PCR ELISA detected very high expression in all adult and fetal tissues and all specific brain regions examined.The deduced 1,491-amino acid protein contains a PDZ domain, a pleckstrin homology (PH) domain, and a RhoGAP domain. ARHGAP23 differs significantly from ARHGAP21 at its C-terminal end.