Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. ARHGEF5 may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.

The 2.3-kb TIM cDNA encodes a predicted protein of 60-kD containing a Dbl-homology (DH) domain. The DH motif is shared by several signal transducing molecules that are implicated as regulators of small GTP-binding proteins. Therefore, the TIM oncogene is also thought to be involved in the control of cytoskeletal organization through regulation of small GTP-binding proteins.