Ribosomal Protein S19 Binding Protein 1 (RPS19BP1)

Rps19bp1 encodes a deduced 142-amino acid protein with a predicted molecular mass of approximately 16 kD. The protein contains 2 basic amino acid clusters, one of which has a variable polylysine tract embedded in a putative nucleolar localization signal. Immunofluorescence localization experiments in Cos-7 cells demonstrated colocalization of Rps19bp1 and Rps19 in the nucleolus, with partial diffusion of Rps19bp1 into the nucleoplasm.The deduced protein contains 142 amino acids. Northern blot analysis detected AROS expression in heart, liver, small intestine, and lung. Endogenous AROS showed nuclear localization in a human lung cancer cell line. Fluorescence-tagged AROS was dispersed in the nucleoplasm in half of transfected cells and showed distinct nuclear foci in the other half.