Ribosomal Protein S6 Kinase Like Protein 1 (RPS6KL1)

In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, MAPK-activated protein kinase-1 (MAPKAP-K1), and S6-H1 Kinase or simply S6 Kinase. There are three variants of p90^rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2. Rsk is named for ribosomal protein s6, part of the mechanism of translation, but several other substrates have been identified, including other ribosomal proteins.