Ribosomal Protein S6 Modification Like Protein A (RIMKLA)

RIMKLA Belongs to the rimK family.Contains 1 ATP-grasp domain.Synthesize N-acetylaspartylglutamate (NAAG), the most abundant dipeptide present in vertebrate central nervous system (CNS), and beta-citrylglutamate, a structural analogue of NAAG present in testis and immature brain.
RIMKLA, is almost exclusively expressed in the CNS, whereas RIMKLB, which shares 65% sequence identity with RIMKLA, is expressed in CNS and testis. RIMKLA catalyzed the ATP-dependent synthesis of N-acetylaspartylglutamate from N-acetylaspartate and l-glutamate. RIMKLB catalyzed this reaction as well as the synthesis of beta-citrylglutamate. The nature of the reaction products was confirmed by mass spectrometry and NMR.