Ribosomal RNA Processing 1 Homolog (RRP1)

RRP1 is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA.

In addition to the 2 C-terminal nuclear localization signals, NOP52 has 4 coiled-coil domains in its C-terminal half. It shares 36% amino acid identity with yeast Rrp1, a protein involved in processing and maturation of 27S rRNA. Indirect immunofluorescence localized NOP52 to nucleoli, with more intense staining at the nucleolar periphery than internal regions. From prophase to late telophase of mitosis, NOP52 localized to the periphery of chromosomes.