Ring Finger Protein 114 (RNF114)

RNF114,The deduced 25.7-kD protein belongs to a family of RING domain E3 ubiquitin ligases characterized by 3 zinc fingers and a ubiquitin-interacting motif. Real-time PCR detected high ZNF313 expression in testis and much lower expression in all other tissues examined. ZNF313 was also expressed in skin, CD4 -positive T cells, and immature and mature dendritic cells. The RING finger domain is a type of zinc finger which contains a Cys₃HisCys₄ amino acid motif which binds two zinc cations. This protein domain contains from 40 to 60 amino acids. The acronym RING stands for Really Interesting New Gene.Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule.