Ring Finger Protein 133 (RNF133)

RNF133 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.

Rnf133 belongs to the RING finger protein (RNF) family, whose members are very divergent in terms of their sequences and functions except for sharing a RING domain. A number of RNFs have been reported to be expressed in the testis, but their functions are poorly understood. Multiple sequence alignment of Rnf133 proteins from five mammalian species.Rnf133 mRNA started to appear in the testis of day 21 mice and increased dramatically from day 28 and thereafter. As round spermatids appear by day 21 during spermatogenesis in mice, Rnf133 seemed to be expressed by round spermatids.