Ring Finger Protein 25 (RNF25)

E3 ubiquitin-protein ligase RNF25 is an enzyme contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. The RING finger domain is a type of zinc finger which contains a Cys₃HisCys₄ amino acid motif which binds two zinc cations.The acronym RING stands for Really Interesting New Gene.Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule.