Round Spermatid Basic Protein 1 Like Protein (RSBN1L)

RSBN1L belongs to the round spermatid basic protein 1 family. 2 isoforms of the human protein are produced by alternative splicing. The spermatid is the haploid male gametid that results from division of secondary spermatocytes. As a result of meiosis, each spermatid contains only half of the genetic material present in the original primary spermatocyte.Spermatids are connected together by cytoplasmic material and have superfluous cytoplasmic material around their nuclei. The spermatids begin to grow a living thread, develop a thickened mid-piece where the mitochondria become localised and form an acrosome. Spermatid DNA also undergoes packaging, becoming highly condensed. The DNA is packaged firstly with specific nuclear basic proteins, which are subsequently replaced with protamines during spermatid elongation.