SAM Domain And HD Domain Containing Protein 1 (SAMHD1)

Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) able to induce a primary T-cell response in vivo. With maturation, DCs shift from antigen-uptake and -processing functions to an antigen-presentation phenotype.

The deduced 626-amino acid protein, which is 72% identical to mouse Mg11, contains several phosphorylation and N-myristoylation sites, an N-glycosylation site, and an amidation site. It has no signal peptide or transmembrane region, suggesting that DCIP is an intracellular protein. RT-PCR analysis detected wide but variable expression in most cell lines tested. Northern blot analysis revealed expression of a 5.2-kb transcript in all tissues tested except brain and thymus.