SEC14 Like Protein 4 (SEC14L4)

SEC14L4 is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants.The 406-amino acid SEC14L4 protein has a conserved CRAL/TRIO domain and shares 80% similarity with SEC14L2. All 3 proteins share residues glu185 and lys216, which are predicted to play a role in phospholipid binding and transfer activity in S. cerevisiae Sec14. RT-PCR of human tissues and cell lines detected high SEC14L4 expression in all tissues examined.