SERTA Domain Containing Protein 3 (SERTAD3)

SERTAD3 was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.

The deduced 196-amino acid protein has a calculated molecular mass of approximately 22 kD. The protein has 4 motifs of proline residues arranged similarly to the core consensus sequence for SH3-binding proteins, or the PY motif of WW domain-binding proteins. Northern blot analysis detected a 1.6-kb transcript.