SET And MYND Domain Containing Protein 3 (SMYD3)

SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.

The deduced 428-amino acid protein contains an N-terminal MYND-type zinc finger domain, followed by a SET domain. Northern blot analysis detected a 1.7-kb transcript that was specific to testis and skeletal muscle. Immunohistochemical staining indicated that the subcellular localization of SMYD3 was altered by the density of cultured human hepatoma cells. In synchronized cells, SMYD3 was located mainly in the cytoplasm when the cells were arrested at G0/G1, but it accumulated in the nuclei at S phase and G2/M.