SET Domain Containing Protein 1A (SETD1A)

SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex.

The SET1A protein contains 1,709 amino acids and, like yeast Set1, contains highly conserved SET and post-SET domains at the C terminus that are related to those of the human and Drosophila trithorax protein, as well as an N-terminal region with similarity to the RRM RNA recognition motif found in many RNA-binding proteins. Consistent with the presence of HCF1 in animals but not yeast, the human and C. elegans, but not the yeast, Set1 proteins contain an HCF1-binding motif found in HCF1 Kelch domain-binding proteins such as the transcriptional activator VP16.