SLIT And NTRK Like Protein 5 (SLITRK5)

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins. Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors. The deduced Slitrk5 protein contains an N-terminal signal peptide, followed by 2 LRR domains, a transmembrane domain, and a cytoplasmic domain with 2 putative tyrosine phosphorylation sites. Each LRR domain is flanked by cysteine-rich regions. In situ hybridization of developing mouse brain detected broad Slitrk5 expression, with significant expression in the subventricular zone, cortical plate, thalamus, hypothalamus, and pyramidal cell layer of hippocampus.