SMG1 Homolog (SMG1)

Members of the phosphatidylinositol kinase-related kinase (PIKK) family, such as SMG1, play central roles in cell growth and stress response pathways. SMG1 is involved in nonsense-mediated mRNA decay, genotoxic and oxidative stress pathways, and TNF-induced apoptosis.

The deduced 3,031-amino acid protein has a calculated molecular mass of 340 kD and contains a conserved ATP-binding site, a DXXXXN and a DXX motif within the catalytic domain, and a short FATC C-terminal region common in PIK-related kinases. Northern blot analysis detected wide expression of an 11.6-kb transcript in multiple tissues and cells, with highest expression in heart, skeletal muscle, kidney, and liver.