Adaptor Related Protein Complex 5 Zeta 1 (AP5z1)
SPG48; Zeta5; Spastic Paraplegia 48; AP-5 complex subunit zeta-1
KIAA0415 exists in a core protein complex containing SPG11, SPG15 (ZFYVE26), C20ORF29, and DKFZp761E198. Knockdown of KIAA0415, C20ORF29, or SPG15 in HeLa cells reduced homologous recombination in a test substrate, whereas knockdown of SPG11 or DKFZp761E198 had no effect. Knockdown of KIAA0415 also reduced homologous recombination in U2OS human osteosarcoma cells.The deduced 634-amino acid protein shares weak similarity with cyclin A1 (CCNA1). RT-PCR detected variable KIAA0415 expression in all tissues examined. In vitro-translated KIAA0415 had an apparent molecular mass of 68 kD by SDS-PAGE.KIAA0415 has a putative C-terminal helicase domain characteristic of superfamily 2 (SF2)-type helicases.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Adaptor Related Protein Complex 5 Zeta 1 (AP5z1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Adaptor Related Protein Complex 5 Zeta 1 (AP5z1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Adaptor Related Protein Complex 5 Zeta 1 (AP5z1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Adaptor Related Protein Complex 5 Zeta 1 (AP5z1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Adaptor Related Protein Complex 5 Zeta 1 (AP5z1) ELISA Kit Customized Service Offer