Serum Response Factor Accessory Protein 2 (SAP2)

SAP2 is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.The predicted Net protein contains an ETS domain at the amino terminus that is about 80% similar to the human ELK1 and ELK4 sequences. The authors noted that 2 other domains also show significant similarity to regions of these proteins, and that the 3 genes clearly belong to the ELK family. Two mRNAs of 2.5 and 4.5 kb were detected by Northern blotting.