STAT3 Interacting Protein As A Repressor (SIPAR)

SIPAR may negatively regulate STAT3. A new gene SIPAR(STAT3 interacting protein as a repressor) is involved in the regulation of STAT3 signal pathway.To study SIPAR expression pattern in mouse embryonic development. Methods Using the whole mount in situ hybridization with a digoxigenin labeled probe. Results The results indicated that SIPAR was expressed in otic vesicles and eye vesicles obviously in mouse dpc9.5 embryo.SIPAR continued to expressed in the mouse embryonic brain and vertebral column part from dpc9.5 to dpc 12.5.

Signal transducer and activator of transcription 3 also known as STAT3 is a transcription factor encoded by the STAT3 gene.Stat3 consists of several conserved domains that are important for STAT function.