SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 1 (SMARCA1)

SMARCA1 is a member of the SWI/SNF family of proteins. Two transcript variants encoding different isoforms have been found for this gene.Despite strong homology at the amino acid level, the SNF2L1 gene in the human was not capable of complementing the yeast mutation. Furthermore, in contrast to SNF2 itself, a fusion protein consisting of the DNA binding domain of LexA and the human gene did not transactivate a reporter gene downstream of LexA binding sites in a yeast expression system. The similarity between SNF2L1 and the yeast gene suggested that the mammalian gene is part of an evolutionarily conserved family that has been implicated as a global activator of transcription in yeast, but its function in mammals remains unknown.