Saccharopine Dehydrogenase (SCCPDH)

SCCPDH belongs to the saccharopine dehydrogenase family and is involved in amino acid metabolism.This entry represents saccharopine dehydrogenase and homospermidine synthase.Saccharopine reductase (SR) catalyses the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine . In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase (PF). Saccharopine dehydrogenase can also function as a saccharopine reductase.Homospermidine synthase proteins. Homospermidine synthase (HSS) catalyses the synthesis of the polyamine homospermidine from 2 mol putrescine in an NAD⁺-dependent reaction .