Scavenger Receptor Class F Member 2 (SCARF2)

SCARF2 contains an N-terminal signal sequence, followed by 10 extracellular EGF-like repeats, a transmembrane domain, and a cytoplasmic domain rich in serine, proline, glycine, and arginine residues.

SCARF2 also has 2 extracellular N-glycosylation sites and several potential intracellular phosphorylation sites. Northern blot analysis detected an SCARF2 transcript of about 3.5 kb in most human tissues examined, with highest expression in heart, placenta, lung, kidney, spleen, small intestine, and ovary. This expression pattern was similar to that of SCARF1.Scarf2 has little scavenger receptor activity. In contrast, individual L-cell clones expressing only Scarf1 or Scarf2 showed a much lower tendency to aggregate.