Sel1 Suppressor Of Lin 12 Like Protein (SEL1L)

SEL1L exhibited a tissue-specific pattern of expression: high levels of a single 7.5-kb transcript were detected only in the pancreas of healthy individuals, whereas low to undetectable levels were observed in other adult tissues and in some fetal tissues.17% of adenocarcinomas of the pancreas did not express SEL1L to a detectable level; however, no gross genomic alterations were apparent within a few hundred kb of the relevant region. SEL1L immunoprecipitated with a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the ER lumen to the cytosol. Other proteins associated with the dislocation complex included HRD1 (SYVN1), derlin-2 (DERL2), the ATPase p97 (VCP), PDI (P4HB), BIP (HSPA5), calnexin (CANX), AUP1, UBXD8 (FAF2), UBC6E (UBE2J1), and OS9 .