Semaphorin 6A (SEMA6A)

SEMA6A consists of 20 exons, including 2 untranslated exons, covering approximately 60 kb of genomic sequence on chromosome 5. Northern blot analysis revealed two 5- and 7-kb SEMA6A transcripts of equal intensity in human embryonic and adult tissues. Highest expression was observed in embryonic brain and kidney, whereas only low to moderate expression was seen in developing lung and liver. Only small amounts of SEMA6A transcripts were detected in human adult tissues, with the exception of rather strong expression levels in the highly regenerative placental tissues. Upon in situ hybridization, mouse neural embryonic tissues displayed high levels of Sema6a mRNA expression in proliferating zones, in the diencephalon, retina, in dorsal root ganglia, and the trigeminal ganglion.