Sentrin Specific Protease 2 (SENP2)

SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.The 3-prime untranslated region of the transcript contains several Alu repeats. RT-PCR ELISA detected very high expression in amygdala and moderate to high expression in whole brain and all other tissues and specific brain regions examined.SENP2 bound specifically to the C-terminal FG-repeat domain of NUP153, indicating that NUP153 plays a role in localizing SENP2 to the nuclear pore. The protein has a calculated molecular mass of 62 kD. Mouse Senp2 is almost identical to human SENP2, although the N terminus of mouse Senp2 is shorter. RT-PCR detected Senp2 expression in mouse brain, heart, and thymus, and in a mouse fibroblast cell line.