Serine Incorporator 5 (SERINC5)

C5orf12 is a putative membrane protein belonging to the TMS_TDE family. The cDNA encodes 423 amino acid with a putative molecular weight of about 47 KDa.

Secondary structure prediction showed that C5orf12 contained 10 putative transmembrane helices, which has high identity with other family members. C5orf12 was highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte while expressed weakly in heart and liver. C5orf12 has high identity with the rat TPO1, C5orf12 may also have a role in the brain development. Myelin throughout the brain is enriched with Serinc5, which was down-regulated in the hippocampus by seizures.