Serine/Threonine Kinase 11 (STK11)

LKB1; PJS; Polarization-Related Protein LKB1; Peutz-Jeghers Syndrome; Liver kinase B1; Renal carcinoma antigen NY-REN-19
Serine/Threonine Kinase 11 (STK11)
LKB1 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It is now clear that LKB1 exerts its growth suppressing effects by activating a group of other ~14 kinases, comprising AMPK and AMPK-related kinases. Activation of AMPK by LKB1 suppresses growth and proliferation when energy and nutrient levels are scarce. Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate expansion of tumour cells. A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour growth under energetically unfavorable conditions.
Organism species: Homo sapiens (Human)
  • Protein RPH115Hu01Recombinant Serine/Threonine Kinase 11 (STK11)Customize
  • AntibodyPAH115Hu01Polyclonal Antibody to Serine/Threonine Kinase 11 (STK11)Customize
  • AntibodyMAH115Hu21Monoclonal Antibody to Serine/Threonine Kinase 11 (STK11)Customize
  • Assay KitSEH115HuELISA Kit for Serine/Threonine Kinase 11 (STK11)Customize
  • Assay KitSCH115HuCLIA Kit for Serine/Threonine Kinase 11 (STK11)Customize
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPH115Ra01Recombinant Serine/Threonine Kinase 11 (STK11)Customize
  • AntibodyPAH115Ra01Polyclonal Antibody to Serine/Threonine Kinase 11 (STK11)Customize
  • AntibodyMAH115Ra21Monoclonal Antibody to Serine/Threonine Kinase 11 (STK11)Customize
  • Assay KitSEH115RaELISA Kit for Serine/Threonine Kinase 11 (STK11)Customize
  • Assay KitSCH115RaCLIA Kit for Serine/Threonine Kinase 11 (STK11)Customize
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