Serine/Threonine Kinase 19 (STK19)

STK19 encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. STK19 protein has an extremely hydrophilic N-terminal half and a C-terminal half with alternating hydrophilic and hydrophobic regions. STK19 contains a positively charged putative nuclear localization signal, multiple potential phosphorylation sites, 2 amidation sites, 9 potential N-myristoylation sites, and no N-glycosylation sites. The 5-prime region of the STK19 gene is rich in CpG sequences, which is typical of a housekeeping gene, and there are 8 Alu elements in intron 4.