Serine/Threonine Kinase 4 (STK4)

STK4 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.

Sequence analysis indicated that the N terminus of the deduced 487-amino acid STK4 protein contains the 11 subdomains typical of an STK. The C terminus of STK4 is highly acidic.