Sex Determining Region Y Box Protein 4 (SOX4)

SOX4 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate.SOX4 may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin).

The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.