Sex Determining Region Y Box Protein 5 (SOX5)

SOX5 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.The deduced mouse and human SOX5 proteins have 97% sequence similarity and an identical HMG box. The SOX5 cDNA clones have variable 5-prime regions resulting from differential splicing.