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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Signal Transducer And Activator Of Transcription 3 (STAT3)
APRF; Acute-Phase Response Factor
STAT3, a transcription factor for acute phase response genes, acts as an adaptor molecule in signal transduction from the type I interferon receptor. They found that it binds to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and undergoes interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol 3-kinase, which activates a series of serine kinases, was found to bind to phosphorylated STAT3 and subsequently to undergo tyrosine phosphorylation. The authors concluded that STAT3 acts as an adaptor to couple another signaling pathway to the interferon receptor.In many human cancers and transformed cell lines, STAT3 is persistently activated, and in cell culture, active STAT3 is either required for transformation, enhances transformation, or blocks apoptosis.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPB743Mu01 Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
RPB743Mu02 Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
Antibodies PAB743Mu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
PAB743Mu02 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
PAB743Mu71 Biotin-Linked Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) Customize
MAB743Mu21 Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) Customize
Assay Kits SEB743Mu ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
SCB743Mu CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPB743Ra01 Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
RPB743Ra02 Recombinant Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
Antibodies PAB743Ra01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
PAB743Ra02 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
MAB743Ra21 Monoclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) Customize
Assay Kits SEB743Ra ELISA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) In Stock
SCB743Ra CLIA Kit for Signal Transducer And Activator Of Transcription 3 (STAT3) Customize