Home  |   About us
ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Signal Transducer And Activator Of Transcription 4 (STAT4)
STAT4 is phosphorylated in response to interleukin-12  and is essential for IL12 signal transduction. For further information on STATs. STAT4 and STAT1, which both map to chromosome 2q32, may have arisen via a tandem gene duplication. However, STAT1 was expressed ubiquitously, whereas STAT4 was expressed in specific tissues, including spleen, heart, brain, peripheral blood cells, and testis. STAT4 expression was drastically increased in T cells following treatment with a DNA methyltransferase inhibitor. Truncation of methylation sites in the proximal regulatory elements of the STAT4 promoter markedly enhanced transcriptional activity. The N-terminal protein interaction domain (N domain) of STAT4 is required for STAT4 activation after IL12 signaling.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPB739Mu01 Recombinant Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
Antibodies PAB739Mu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
MAB739Mu21 Monoclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
Assay Kits SEB739Mu ELISA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
SCB739Mu CLIA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPB739Ra01 Recombinant Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
Antibodies PAB739Ra01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
MAB739Ra21 Monoclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
Assay Kits SEB739Ra ELISA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4) Customize
SCB739Ra CLIA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4) Customize