Signal Transducer And Activator Of Transcription 4 (STAT4)

Signal Transducer And Activator Of Transcription 4 (STAT4)
STAT4 is phosphorylated in response to interleukin-12  and is essential for IL12 signal transduction. For further information on STATs. STAT4 and STAT1, which both map to chromosome 2q32, may have arisen via a tandem gene duplication. However, STAT1 was expressed ubiquitously, whereas STAT4 was expressed in specific tissues, including spleen, heart, brain, peripheral blood cells, and testis. STAT4 expression was drastically increased in T cells following treatment with a DNA methyltransferase inhibitor. Truncation of methylation sites in the proximal regulatory elements of the STAT4 promoter markedly enhanced transcriptional activity. The N-terminal protein interaction domain (N domain) of STAT4 is required for STAT4 activation after IL12 signaling.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
  • Protein RPB739Mu01Recombinant Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
  • AntibodyPAB739Mu01Polyclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
  • AntibodyMAB739Mu21Monoclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
  • Assay KitSEB739MiELISA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4)In Stock
  • Assay KitSCB739MiCLIA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPB739Ra01Recombinant Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
  • AntibodyPAB739Ra01Polyclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
  • AntibodyMAB739Ra21Monoclonal Antibody to Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
  • Assay KitSEB739MiELISA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4)In Stock
  • Assay KitSCB739MiCLIA Kit for Signal Transducer And Activator Of Transcription 4 (STAT4)Customize
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