Sine Oculis Binding Protein (SOBP)

SOBP contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif (PR2).

SOBP was expressed in various human tissues. In situ hybridization detected Sobp expression throughout developing mouse brain at embryonic day 14, with intense staining in the cortical plate. In postnatal and adult mouse brain, Sobp was expressed in all neurons, with intense staining in the limbic system. Highest expression was in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of Sobp in the limbic system corresponded to a time of active synaptogenesis.