Single Stranded DNA Binding Protein 2 (SSBP2)

SSBP2 is a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability. The deduced 362-amino acid SSBP2 protein shares 83% and 73% sequence identity with SSBP3 and SSBP4, respectively, and 100% identity with the mouse Ssbp2 homolog. SSBP family members share a highly conserved N terminus followed by a glycine- and proline-rich domain. Northern blot analysis detected ubiquitous expression of a 1.9-kb SSBP2 transcript. Expression was high in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression was also high in heart, brain, kidney, and skeletal muscle. Of 5 leukemia cell lines tested, expression was highest in pre-T lymphoblastic leukemia cell line CEM.