Single Stranded DNA Binding Protein 3 (SSBP3)

SSBP3 is the human homolog of the chicken gene CSDP, which encodes a protein that binds single-stranded pyrimidine-rich mirror-repeat elements with high specificity. The deduced 363-amino acid SSBP3 protein shares 83% and 72% sequence identity with human SSBP2 and SSBP4, respectively. SSBP family members share a highly conserved N terminus followed by a glycine- and proline-rich domain.

SSBP2, SSBP3, and SSBP4 genes all contain 17 exons and have identical intron/exon boundaries, suggesting duplication from a common ancestral gene. They also identified alternative splicing and additional internal exons for all 3 genes, suggesting the existence of multiple isoforms for each protein. The SSBP3 gene spans more than 100 kb.