Single Stranded DNA Binding Protein 4 (SSBP4)

All 3 SSBP genes share homology with the chicken gene CSDP, which encodes a protein that binds single-stranded pyrimidine-rich mirror-repeat elements with high specificity. The deduced 364-amino acid SSBP4 protein shares 73% and 72% sequence identity with human SSBP2 and SSBP3, respectively. SSBP family members share a highly conserved N terminus followed by a glycine- and proline-rich domain.

SSBP2, SSBP3, and SSBP4 genes all contain 17 exons and have identical intron/exon boundaries, suggesting duplication from a common ancestral gene. They also identified alternative splicing and additional internal exons for all 3 genes, suggesting the existence of multiple isoforms for each protein. The SSBP4 gene spans less than 25 kb.