Skin Specific Protein 32 (XP32)

XP32 Expressed at high levels in normal and psoriatic skin, but not in normal keratinocytes, A431 cells, or any of the other cell lines or tissues tested.

Chromosome 1 is the largest of the human chromosomes, containing approximately 8% of all human genetic information. Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes, and many coding sequences overlap. Rearrangements and mutations of chromosome 1 are prevalent in cancer and many other diseases. Patterns of sequence variation reveal signals of recent selection in specific genes that may contribute to human fitness, and also in regions where no function is evident. Fine-scale recombination occurs in hotspots of varying intensity along the sequence, and is enriched near genes.