Small G Protein Signaling Modulator 1 (SGSM1)

SGSM1 transcript predominantly in adult heart, brain, kidney, pancreas, and testis; in fetal brain, skeletal muscle, and heart; and in nearly all specific adult brain regions examined. In mouse, Sgsm1 was detected only in adult brain and there was evidence of splice variants. In situ hybridization and immunohistochemical analysis of adult mouse brain showed that Sgsm1 was predominantly expressed in the layer of Ammon's horn (CA1, CA2, CA3), in dentate gyrus, hippocampus, granular and Purkinje cell layer of cerebellum, and in neurons of the cerebral cortex. Immunofluorescence analysis detected endogenous Sgsm1 associated with the Golgi apparatus in a mouse neuroblastoma cell line.SGSM1 interacted with endogenous Rap1 and Rap2.