Small Glutamine Rich Tetratricopeptide Repeat Containing Protein Alpha (SGTa)

SGTa encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.

The SGT gene encodes a 313-amino acid polypeptide containing 3 tetratricopeptide repeat (TPR) protein-protein interaction motifs. The complex functioned as an ATP-dependent chaperone that reactivated a denatured substrate. Sgt overexpression in cultured rat hippocampal neurons inhibited neurotransmitter release, suggesting that the Csp/Sgt/Hsc70 complex is important for maintenance of a normal synapse.