Soc2 Suppressor Of Clear Homolog (SHOC2)

SHOC2 encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. soc2 encodes a protein composed almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. Sur8 encodes a conserved protein that is composed predominantly of leucine-rich repeats. The sur8 protein interacts directly with Ras but not with the Ras(P34G) mutant protein, suggesting that sur8 may mediate its effects through Ras binding.