Sodium Channel And Clathrin Linker 1 (SCLT1)

SCLT1 acts as a linker protein between the voltage-gated sodium channel Na(v)1.8 (SCN10A) and clathrin . The deduced 688-amino acid human SCLT1 protein shares 76% sequence identity with the rat protein. SCLT1 contains a myosin tail domain (MTD), a vacuolar ATPase homology domain (V-pump), and dileucine motifs in the C terminal terminus. SCLT1 lacks a signal peptide and transmembrane segments. Immunofluorescence studies detected rat Sclt1 protein in dorsal root ganglion (DRG) neurons and sciatic nerve C-type fibers with low immunostaining in the cerebellum. No signal was detected in liver or heart. Immunostaining studies colocalized rat Sclt1 with Scn10a in DRG neurons and with clathrin within subsurface regions of the DRG.