Solute Carrier Family 13, Member 4 (SLC13A4)

SUT1 belongs to the family of sodium-coupled anion transporters and exhibits 40 to 50% amino acid identity with the rat renal sodium/sulfate cotransporter NaSi1, as well as with the human and rat sodium/dicarboxylate cotransporters NADC1/SDCT1 and NADC3/SDCT2.

Functional expression studies in cRNA-injected Xenopus laevis oocytes showed that SUT1 mediates high levels of sodium-dependent sulfate transport, which is resistant to DIDS inhibition. Northern blot analysis showed that SUT1 exhibits a highly restricted tissue distribution, with abundant expression in placenta.SUT1 and DTDST may correspond, respectively, to the DIDS-resistant and DIDS-sensitive components of sulfate uptake in HEVEC.