Solute Carrier Family 17, Member 6 (SLC17A6)

SLC17A6 contains 8 putative transmembrane segments. SLC17A6 shares 82% sequence identity with SLC17A7, which the authors called BNPI, and 48% identity with EAT4, a sodium-inorganic phosphate cotransporter of C. elegans. Northern blot analysis detected SLC17A6 transcripts of 4.1 and 4.4 kb expressed predominantly in adult and fetal brain. Analysis of specific brain regions indicated highest expression in medulla, substantia nigra, subthalamic nucleus, and thalamus, with low levels in cerebellum and hippocampus. Mouse Slc17a6 contains 582 amino acids and shares 97% sequence identity with human SLC17A6. In situ hybridization of mouse brain slices showed expression in neuron-rich regions of the cerebral cortex, hippocampus, hypothalamus, and thalamus.