Sodium Dependent Vitamin C Transporter 2 (SVCT2)

The absorption of vitamin C into the body and its distribution to organs requires the sodium-coupled vitamin C transporters SVCT1 and SVCT2. SVCT1 is largely confined to epithelial surfaces involved in bulk transport, such as those of the intestine and kidney, and is involved in maintenance of whole-body homeostasis, through dietary absorption and renal reabsorption. SVCT2 appears to account for tissue-specific uptake of vitamin C. SVCT2 expression is widespread, occurring in neurons, the endocrine system, bone, and other tissues, thus protecting metabolically active tissues from oxidative stressSVCT2 is expressed in a host of metabolically active cells and specialized tissues in the brain, eye, and other organs. SVCT2 has 12 transmembrane domains, 2 possible sites for N-glycosylation, and multiple potential phosphorylation sites.