Solute Carrier Family 24, Member 3 (SLC24A3)

Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions.

The deduced 644-amino acid protein contains 11 transmembrane segments and 2 alpha-repeat regions. It also contains 2 putative glycosylation sites at the N terminus and several putative phosphorylation sites in the central presumptive cytoplasmic loop. Human KCNX3 shares over 95% amino acid identity with mouse and rat Nckx.NCKX3 was also highly expressed in aorta, uterus, and skeletal muscle. In vitro translation resulted in a protein of about 72 kD.