Sodium/Calcium Exchanger Protein, Mitochondrial (NCLX)

SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion .

The deduced 584-amino acid human protein shares 83% amino acid identity with the 585-amino acid mouse protein. The NCKX6 protein sequence contains 13 transmembrane segments with a potential cleavage site for signal peptidase and 2 N-glycosylation sites on the extracellular loop between the first and second transmembrane segments, and 2 putative phosphorylation sites in the large intracellular loop between the sixth and seventh transmembrane segments. This variant lacks exons 13 and 14, and encodes a protein that differs from the long form after the tenth transmembrane domain.