Solute Carrier Family 35, Member B1 (SLC35B1)

Sulfation of a variety of molecules, including glycoproteins, proteoglycans, and glycolipids, requires 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS), a high-energy form of the universal sulfate donor.

SLC35B1 translocates PAPS from the cytosol or nucleus, where it is synthesized, to the Golgi lumen for use. By searching databases for sequences similar to UGT1 (SLC35A2), followed by 5-prime RACE of human adult and fetal liver cDNA libraries, Ishida et al. (1996) identified SLC35B1, which they called UGTREL1. They also cloned the mouse and rat homologs.The International Radiation Hybrid Mapping Consortium mapped the SLC35B1 gene to chromosome 17.