Solute Carrier Family 39, Member 14 (SLC39A14)

SLC39A14 contains a long N terminus, followed by 8 putative transmembrane domains and a short C terminus. It also has a motif similar to the catalytic zinc-binding site of matrix metalloproteases. Expression of SLC39A14 in Chinese hamster ovary cells showed an apparent molecular mass of 53 kD and suggested SLC39A14 has up to 3 N-linked carbohydrate side chains.

Under nonreducing conditions, SLC39A14 migrated as a trimer, consistent with the formation of an ion channel. SLC39A14 was expressed on the plasma membrane, colocalized with F-actin, and concentrated on lamellipodiae in a manner similar to membrane-type matrix metalloproteases.